Saturday, 25 January 2014

AETIOLOGY, EPIDEMIOLOGY AND PATHOGENESIS OF CANCER IN MAN


ABSTRACT
Cancer is a disease caused by uncontrolled growth of abnormal cells. The disease is capable of affecting any part of the body such as the reproductive organs, respiratory organs, digestive and excretory organs. It has no prediliction for race, age, colour or status, as it affects children, infants and adults. This paper discusses its causes, spreading and how it is formed. It also focuses on its symptoms, treatment and how frequent it occurs. The aetiological agent of this disease is the main focus for its prevention as some of the disease is incurable.


INTRODUCTION
Cancer is a term used to define the diseases with which abnormal cells have the ability to invade tissues within the body and are spread through the blood stream and lymph system (Parvesh, 2009).
They are characterized by excessive, uncontrolled growth of abnormal cells, which invade and destroy the other tissues of the body but certain types of cancer are more life-threatening than others.
Cancer is one of the most serious medical problems in developed nations. A tumor (Latin tumere; to swell) is a growth or lump of tissue resulting from neoplasia, abnormal new cell growth and reproduction due to loss of regulation. Tumor cells have aberrant shapes and altered plasma membranes that may contain distinctive tumor antigens. Their unregulated proliferation and loss of differentiation results in invasive growth that forms unorganized cell masses (Flint et al 2004). This reversion to a more primitive or less differentiated state is called anaplasia. There are two major types of tumor with respect to their overall form or growth pattern. If the tumor cells remain in place to form a compact mass, the tumor is benign. In contrast, cells from malignant or cancerous tumors can actively spread throughout the body in a process known as metastasis, often by floating in the blood and establishing secondary tumors.



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